Healthcare institutions are moving to integrate health data sources using Electronic Health Record (EHR) systems delivered over wireless networks. Such applications allow disparate electronic patient information to be input by different caregivers at different locations and to be stored as encapsulated patient profiles. Our mobile medical system allows doctors to efficiently record and access complete and accurate real-time patient data at the point-of-care. The system fuses important multimedia patient data such as medical imagery with textual patient profiles. It also combines expert interactions by caregivers with patient cases using Case-Based Reasoning (CBR) and Knowledge Management (KM) techniques. By capturing specialist decision-making the application can provide decision support that assists caregivers in quickly retrieving the most similar patient cases from large repositories of medical records to support effective diagnoses by comparing symptoms, treatments, diagnoses and other patient information. In this paper we present an overview of a case-based multimedia medical decision support application and an evaluation with actual electronic patient medical records.